Major current projects include:
1. ACORN: The Arthroplasty Clinical Outcomes Registry, National. This is the first multicentre registry of patient-relevant outcomes after joint replacement surgery. Currently, there is no standardised measurement of how well hip and knee replacement surgery is performing, apart from the National Joint Replacement Registry (NJRR). The NJRR measures re-operation as the main indicator of performance, but unlike many registries internationally, it does not measure relief of pain, improvement in function, or overall satisfaction – the outcomes of interest to the patients and outcomes that measure the effectiveness of this type of surgery in achieving its goals.
2. ANZHFR: The ANZ Hip Fracture Registry. The National Hip Fracture Database in the UK has led to improvement in the processes and outcomes of care for elderly patients with hip fractures. Professor Harris co-chairs the ANZ Hip Fracture Registry which has been established to measure outcomes of care in all hospitals in Australia and New Zealand that treat hip fractures. The registry aims to improve care incrementally, and to document that improvement, by feeding back the outcomes to the institutions and the public. The registry has developed NHMRC approved guidelines for hip fracture care and is currently assisting the Australian Commission on Quality and Safety in Health Care in developing national Standards of Care. The first hospitals started entering registry data at the end of 2014 and we aim to have 25 hospitals recruiting by the end of 2015.
3. CROSSBAT: A multicentre randomised trial of operative versus non-operative treatment for ankle fractures. This is one of the largest multicentre randomised trials in orthopaedics. It compares the results of surgical treatment to non-operative treatment for common ankle fractures. Currently nearly half of these fractures are treated surgically, and there is considerable variation in recommendations across the country. The results of this study will mean that treatment can be based on high level evidence so that all future patients with these common injuries can be treated with the optimum treatment. The success of this study has spurred new, similar multicentre studies that will begin in 2015.
4. Multicentre study exploring the association between protocol adherence and clinical outcomes in total joint replacement surgery. Total hip and knee replacement surgery is common, effective and expensive. However, there exists considerable variation in the protocols and procedures around the care of these patients, for example, treatments aimed at avoiding complication such as infection and venous clots and emboli. We have performed a multicentre study across the country involving nearly 2,000 patients to determine the degree of treatment variation and to determine the effect of that variation on the outcomes of hip and knee replacement surgery. This will be the largest study of its kind and the results are expected to lead to an improvement in the care of joint replacement patients and a subsequent improvement in outcomes. In addition to exploring the relationship between the care received intended to prevent infection and clots, the study will provide numerous insights into other aspects of care of import in this area including: whether inpatient rehabilitation is associated with better outcomes after surgery; whether an anterior approach is better than a posterior approach after hip replacement; whether satisfaction with the acute care experience is higher amongst patients treated in the private sector.
5. HIHO: A multicentre randomised trial of hospital inpatient rehabilitation versus a home exercise program after total knee replacement. In Australia, and in NSW in particular, it is common to have inpatient rehabilitation after total knee replacement surgery. However, this is expensive and the evidence supporting this practice is lacking. We have conducted a multicentre randomised trial of inpatient versus a monitored home rehabilitation after knee replacement surgery. This study will provide high level evidence that will either support or refute current practice. This study adds to the program of work undertaken by the Centre in this area.
6. ANZMUSC. The Whitlam Orthopaedic Research Centre is part of the organising group that is establishing ANZMUSC: the Australian and New Zealand Musculoskeletal Clinical Trials Network. The first meeting was held in 2014 and this group aims to improve the quality and impact of randomised trials in musculoskeletal medicine. The group of senior and emerging researchers from both countries will establish priority areas to study and will review and approve trials, and support applications for funding.
7. Opioid use in orthopaedics and trauma. The research centre has undertaken several studies exploring the impact of opioid use, and the incidence of opioid dependence after injury. Using this experience, the Centre was able to secure funding to begin a randomised trial comparing major opioids to “over the counter” opioids for patients discharged after orthopaedic fracture treatment. This study has the potential to reduce costs and harms associated with the routine use of major opioids.
8. Consumer and clinician perspectives on the role of and need for inpatient rehabilitation after knee or hip replacement. In order for new or alternative models of care to be acceptable to consumers and clinicians alike, we need to understand why people regard inpatient rehabilitation as an important part of the recovery after joint replacement surgery. This study adds to the program of work undertaken by the Centre in this area.
C1 - Journal Article
- Goyal N, Chen DB, Harris IA, Rowden NJ, Kirsh G, MacDessi SJ 2016, "Intravenous vs Intra-Articular Tranexamic Acid in Total Knee Arthroplasty: A Randomized, Double-Blind Trial", Journal of Arthroplasty
- Gharaibeh MA, Solayar GN, Harris IA, Chen DB, MacDessi SJ 2016, "Accelerometer-Based, Portable Navigation (KneeAlign) vs Conventional Instrumentation for Total Knee Arthroplasty: A Prospective Randomized Comparative Trial", Journal of Arthroplasty
- Sarrami P, Armstrong E, Naylor JM, Harris IA 2016, "Factors predicting outcome in whiplash injury: a systematic meta-review of prognostic factors", Journal of Orthopaedics and Traumatology, pp. 1-8
- Ekmejian R, Sarrami P, Naylor JM, Harris IA 2016, "A systematic review on the effectiveness of back protectors for motorcyclists", Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, vol. 24, no. 1
- Aggarwal A, Harris IA, Naylor JM 2016, "Patient preferences for emergency or planned hip fracture surgery: A cross-sectional study", Journal of Orthopaedic Surgery and Research, vol. 11, no. 1
- Buchbinde R, Harris I 2016, "Treatment of meniscal tear", Annals of Internal Medicine, vol. 165, no. 8, pp. 602-603
- Gopinath B, Jagnoor J, Harris IA, Nicholas M, Casey P, Blyth F, Maher CG, Cameron ID 2016, "Health-related quality of life 24 months after sustaining a minor musculoskeletal injury in a road traffic crash: a prospective cohort study.", Traffic Inj Prev
- Murgatroyd DF, Harris IA, Tran Y, Cameron ID 2016, "Erratum: Predictors of return to work following motor vehicle related orthopaedic trauma (BMC Musculoskeletal Disorders (2016) 17 (171) DOI: 10.1186/s12891-016-1019-6)", BMC Musculoskeletal Disorders, vol. 17, no. 1
- Mittal R, Harris IA, Adie S, Naylor JM 2016, "Factors affecting patient participation in orthopaedic trials comparing surgery to non-surgical interventions", Contemporary Clinical Trials Communications, vol. 3, pp. 153-157
- Sutherland J, Harris I 2016, Surgery-risks, benefits and the value of shared decision-making, Anaesthesia and Intensive Care, Australian Society of Anaesthetists, vol. 44, no. 3, pp. 338-339
- Machado GC, Ferreira PH, Yoo RI, Harris IA, Pinheiro MB, Koes BW, van Tulder MW, Rzewuska M, Maher CG, Ferreira ML 2016, "Surgical options for lumbar spinal stenosis", Cochrane Database of Systematic Reviews, vol. 2016, no. 11
- Isedale G, Harris I, Rider M 2016, "Improving hand surgery access and care through service redesign.", ANZ Journal of Surgery
- Wu J, Faux SG, Harris I, Poulos CJ, Alexander T 2016, "Record linkage is feasible with non-identifiable trauma and rehabilitation datasets.", Australian and New Zealand Journal of Public Health
- Mulford JS, Watson A, Broe D, Solomon M, Loefler A, Harris I 2016, "Short-term outcomes of local infiltration anaesthetic in total knee arthroplasty: a randomized controlled double-blinded controlled trial.", ANZ Journal of Surgery
- Mathieson S, Billot L, Maher CG, McLachlan AJ, Latimer J, Koes BW, Hancock MJ, Harris I, Day RO, Pik J, Jan S, Lin CWC 2016, "PRECISE - pregabalin in addition to usual care: Statistical analysis plan", Trials
- Khatib Y, Jenkin D, Naylor JM, Harris IA 2016, "Psychological Traits in Patients Waiting for Total Knee Arthroplasty. A Cross-sectional Study.", Journal of Arthroplasty
- Wu J, Faux SG, Harris I, Poulos CJ 2016, "Integration of trauma and rehabilitation services is the answer to more cost-effective care.", ANZ Journal of Surgery
- Ham A, Goyal N, Harris IA, Chen DB, MacDessi SJ 2016, "Infection rates with use of intra-articular pain catheters in total knee arthroplasty.", ANZ Journal of Surgery
- Goyal N, Kaul R, Harris IA, Chen DB, MacDessi SJ 2016, "Is there a need for routine post-operative hemoglobin level estimation in total knee arthroplasty with tranexamic acid use?", Knee, vol. 23, no. 2, pp. 310-313
- Ginsel B, Aggarwal A, Xuan W, Harris I 2015, "The distribution of probability values in medical abstracts: An observational study Medical Research Methodology", BMC Research Notes, vol. 8, no. 1
- Adie S, Ma D, Harris IA, Naylor JM, Craig JC 2015, "Quality of conduct and reporting of meta-analyses of surgical interventions", Annals of Surgery, vol. 261, no. 4, pp. 685-694
- Machado GC, Ferreira PH, Harris IA, Pinheiro MB, Koes BW, Van Tulder M, Rzewuska M, Maher CG, Ferreira ML 2015, "Effectiveness of surgery for lumbar spinal stenosis: A systematic review and meta-analysis", PloS One, vol. 10, no. 3
- 2015, "Presence and predictors of persistent pain among persons who sustained an injury in a road traffic crash", European Journal of Pain, Elsevier, United Kingdom, vol. 19, no. 8, pp. 1111-1118
- Khatib Y, Madan A, Naylor JM, Harris IA 2015, "Do psychological factors predict poor outcome in patients undergoing TKA? A systematic review", Clinical Orthopaedics and Related Research
- Lin CWC, Day RO, Harris I, Maher CG, McLachlan A 2015, "Comparative efficacy trials with no placebo group cannot determine efficacy", BMJ-British Medical Journal, vol. 350
- Murgatroyd DF, Casey PP, Cameron ID, Harris IA 2015, "The effect of financial compensation on health outcomes following musculoskeletal injury: Systematic review", PloS One, vol. 10, no. 2
- Gopinath B, Harris IA, Nicholas M, Casey P, Blyth F, Maher CG, Cameron ID 2015, "A comparison of health outcomes in older versus younger adults following a road", PloS One, vol. 10, no. 4
- Buchbinder R, Maher C, Harris IA 2015, "Setting the research agenda for improving health care in musculoskeletal disorders", Nature Reviews Rheumatology, vol. 11, no. 10, pp. 597-605
- 2015, "Prognostic indicators of social outcomes in persons who sustained an injury in a road traffic crash", Injury, Elsevier, United Kingdom, vol. 46, no. 5, pp. 909-917
- Adie S, Harris IA, Naylor JM, Mittal R 2015, "Reply to letter: CONSORT Compliance in Surgical Randomized Trials: Possible Solutions", Annals of Surgery, vol. 261, no. 5, p. e135
- Buchbinder R, Harris IA, Sprowson A 2015, Management of degenerative meniscal tears and the role of surgery., BMJ-British Medical Journal, vol. 350, p. h2212
- Verbeek DO, Sugrue M, Balogh Z, Cass D, Civil I, Harris I, Kossmann T, Leibman S, Malka V, Pohl A, Rao S, Richardson M, Schuetz M, Ursic C, Wills V 2015, "Erratum: Acute MANAGEMENT of HEMODYNAMICALLY UNSTABLE PELVIC TRAUMA PATIENTS: Time for a change? Multicenter review of recent practice", World Journal of Surgery, vol. 38, no. 10, p. 2741
- Gopinath B, Jagnoor J, Harris IA, Nicholas M, Maher CG, Casey P, Blyth F, Sindhusake D, Cameron ID 2015, "Comparison of health outcomes between hospitalised and non-hospitalised persons with minor injuries sustained in a road traffic crash in Australia: A prospective cohort study", BMJ Open, vol. 5, no. 9
- Nabavi A, Olwill CM, Harris IA 2015, "Preoperative predictors of outcome in the arthroscopic treatment of femoroacetabular impingement", HIP International, vol. 25, no. 5, pp. 402-405
- Symes M, Harris IA, Limbers J, Joshi M 2015, "SOFIE: Surgery for Olecranon Fractures in the Elderly: A randomised controlled trial of operative versus non-operative treatment Orthopedics and biomechanics", BMC Musculoskeletal Disorders, vol. 16, no. 1
- 2014, "Evidence-based review for patients undergoing elective hip and knee replacement", ANZ Journal of Surgery, Wiley-Blackwell Publishing, Australia, vol. 84, no. 1-2, pp. 17-24
- Abdel Messih M, Naylor JM, Descallar J, Manickam A, Mittal R, Harris IA 2014, "Mail versus telephone administration of the oxford knee and hip scores", Journal of Arthroplasty, vol. 29, no. 3, pp. 491-494
- Marimuthu K, Chen DB, Harris IA, Wheatley E, Bryant CJ, MacDessi SJ 2014, "A multi-planar CT-based comparative analysis of patient-specific cutting guides with conventional instrumentation in total knee arthroplasty", Journal of Arthroplasty, vol. 29, no. 6, pp. 1138-1142
- Naylor JM, Hayen A, Davidson E, Hackett D, Harris IA, Kamalasena G, Mittal R 2014, "Minimal detectable change for mobility and patient-reported tools in people with osteoarthritis awaiting arthroplasty", BMC Musculoskeletal Disorders, vol. 15, no. 1
- Arora M, Diwan AD, Harris IA 2014, Prevalence and factors of burnout among Australian orthopaedic trainees: a cross-sectional study, Journal of Orthopaedic Surgery, vol. 22, no. 3, pp. 374-377
- Harris IA, Naylor JM 2014, "Double standards in clinical practice ethics", Medical Journal Australia, vol. 200, no. 2, p. 76
- Buchbinder R, Richards B, Harris I 2014, "Knee osteoarthritis and role for surgical intervention: Lessons learned from randomized clinical trials and population-based cohorts", Current Opinion in Rheumatology, vol. 26, no. 2, pp. 138-144
- Crane C, Marimuthu K, Chen DB, Harris IA, Wheatley E, MacDessi SJ 2014, "Radiographic outcome of limb-based versus knee-based patient specific guides in total knee arthroplasty", Knee, vol. 21, no. 6, pp. 1244-1249
- Seagrave KG, Naylor J, Armstrong E, Leong KM, Descallar J, Harris IA 2014, "Data quality audit of the arthroplasty clinical outcomes registry NSW.", BMC Health Services Research, vol. 14, p. 512
- Lieu D, Harris IA, Naylor JM, Mittal R 2014, Total hip replacement in haemodialysis or renal transplant patients, Journal of Orthopaedic Surgery, vol. 22, no. 3, pp. 393-398
- Chinnappa J, Chen DB, Harris IA, MacDessi SJ 2014, "Total knee arthroplasty using patient-specific guides: Is there a learning curve?", Knee
- Zeltzer J, Mitchell RJ, Toson B, Harris IA, Close J 2014, "Determinants of time to surgery for patients with hip fracture", ANZ Journal of Surgery, vol. 84, no. 9, pp. 633-638
- Verbeek DO, Sugrue M, Balogh Z, Cass D, Civil I, Harris I, Kossmann T, Leibman S, Malka V, Pohl A, Rao S, Richardson M, Schuetz M, Ursic C, Wills V 2014, "Erratum to: Acute management of hemodynamically unstable pelvic trauma patients: time for a change? Multicenter Review of Recent Practice", World Journal of Surgery, vol. 38, no. 10, p. 2741
- Lim HC, Adie S, Naylor JM, Harris IA 2014, "Randomised trial support for orthopaedic surgical procedures", PloS One, vol. 9, no. 6
- Jang B, Kao M, Bohm MT, Harris IA, Chen DB, MacDessi SJ 2014, Intra-articular injection of tranexamic acid to reduce blood loss after total knee arthroplasty, Journal of Orthopaedic Surgery, vol. 22, no. 2, pp. 146-149
- Zeltzer J, Mitchell RJ, Toson B, Harris IA, Ahmad L, Close J 2014, "Orthogeriatric services associated with lower 30-day mortality for older patients who undergo surgery for hip fracture", Medical Journal Australia, vol. 201, no. 7, pp. 409-411
- Harris I Journal bias or author bias?, Indian J Med Ethics, vol. 1, no. 4, p. 223
- Buchbinder R, Harris IA, Sprowson A "Management of degenerative meniscal tears and the role of surgery.", Br J Sports Med, vol. 50, no. 22, pp. 1413-1416
E1 - Conference Abstract
- 2018 CRISTAL: Cluster Randomised Trial of Aspirin versus Low molecular weight heparin for venous thromboembolism prophylaxis in joint replacement surgery, a registry-nested study Ian Andrew Harris; Stephen Graves; Rachelle Buchbinder; Justine Maree Naylor; Nicole Pratt; Richard de Steiger; Beng Hock Chong; Ilana Ackerman; Sam Adie; Anthony Harris; NATIONAL HEALTH & MEDICAL RESEARCH COUNCIL.
- 2016 CROSSFIRE: Combined Randomised and Observational Study of Surgery for Fractures In the distal Radius in the Elderly Ian Andrew Harris; Rachelle Buchbinder; Rebecca Q Ivers; Justine Maree Naylor; Zsolt Balogh; Paul Smith; NATIONAL HEALTH & MEDICAL RESEARCH COUNCIL.
- 2015 'Foundation of Surgery John Loewenthal Research Fellowship - Scholarship for Dr Rajat Mittal. Ian Andrew Harris; Royal Australasian College of Surgeons.
- 2012 Improving outcomes for people with an osteoporotic hip fracture. Jacqueline Close; Ian Andrew Harris; Mellick Chehade; Gustavo Duque; Hannah Seymour; Laura Ahmad; Roger Harris; Rebecca Mitchell; Paul Mitchell; Stewart Fleming; Bupa Health Foundation.
- 2012 Scholarship for Rajat Mittal - CROSSBAT. Ian Andrew Harris; NATIONAL HEALTH & MEDICAL RESEARCH COUNCIL.
- 2010 The association between quality and effect estimate in surgical trials - Scholarship for Dr Sam Adie Ian Andrew Harris; Whitlam Orthopaedic Research Centre.
- Enhancing joint replacement outcomes through national data linkage Stephen Graves; Nicole Pratt; Maria Inacio; Richard de Steiger; Ian Andrew Harris; Ilana Ackerman; Louisa Ruth Jorm; University of South Australia.